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Istradefylline forty mg/working day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/working day. Consider dose reduction of delicate CYP3A4 substrates.Concomitant usage of fentanyl injection with CYP3A4 inducers or discontinuation of the CYP3A4 inhibitor could reduce fent